In vitro studies were conducted to investigate the potential of gabapentin to inhibit the major cytochrome P450 enzymes CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 that mediate drug and xenobiotic metabolism using isoform selective marker substrates and human liver microsomal preparations. These Medications Have Been Shown To Be More Effective in Double-Blind Studies That Are Placebo Controlled. What are the ingredients in Neurontin? Your doctor may want to check the amount of gabapentin in your blood or change the schedule of your gabapentin dosing. This medicine is available only with your doctor's prescription. purchase generic alesse payment uk
Zhang C, Glenn DG, Bell WL, O'donovan CA "Gabapentin-induced Myoclonus in End-stage Renal Disease. Patients who take gabapentin capsules may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take gabapentin capsules closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
Gabapentin is also used in adults to manage a condition called postherpetic neuralgia, which is pain that occurs after shingles. Some gabapentin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Check with your doctor before you drink alcohol or use medicines that may cause drowsiness eg, sleep aids, muscle relaxers while you are using Neurontin solution; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. If you take an antacid that contains aluminum or magnesium, wait at least 2 hours before taking gabapentin.
Can It Prevent Future Episodes of Mania and Depression? Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Gabapentin is a safe and effective adjuvant analgesic for neuropathic pain. Physicians should become comfortable using and titrating gabapentin in patients with neuropathic pain syndromes. Get emergency medical help if you have any of these signs of an allergic reaction: hives; fever; swollen glands; painful sores in or around your eyes or mouth; difficulty breathing; swelling of your face, lips, tongue, or throat.
AUC in rats is approximately 8 times that in humans at the MRHD. Can Gabapentin Be Used for the Treatment of Mixed Bipolar States? In other countries besides the United States, children have been prescribed Gabapentin. Patients on hemodialysis should receive maintenance doses based on estimates of creatinine clearance as indicated in the upper portion of the table and a supplemental post-hemodialysis dose administered after each 4 hours of hemodialysis as indicated in the lower portion of the table. Thus, cimetidine appeared to alter the renal excretion of both gabapentin and creatinine, an endogenous marker of renal function. This small decrease in excretion of gabapentin by cimetidine is not expected to be of clinical importance. The effect of gabapentin on cimetidine was not evaluated. Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Neurontin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. The amount of gabapentin in your blood may decrease. This may cause an increase in seizures.
The overall incidence of adverse reactions and the types of adverse reactions seen were similar among men and women treated with Neurontin. The incidence of adverse reactions increased slightly with increasing age in patients treated with either Neurontin or placebo. Use Neurontin solution with caution in the ELDERLY; they may be more sensitive to its effects. What is the Typical Final Dose That Would Be Prescribed to Someone Taking Gabapentin? There are claims that Gabapentin was successful in helping with rapid cycling and mixed bipolar states in people who have not received relief from valproate or carbamazepine. It appeared that Gabapentin helped more with anxiety and agitation than the other two drugs. It has also been shown that Gabapentin could aid people with certain types of tardive dyskinesia. Measure the oral liquid using a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Is Gabapentin Available in Countries Other Than the United States? Do not take Neurontin if you are allergic to gabapentin or any of the other ingredients in Neurontin. See the end of this Medication Guide for a complete list of ingredients in Neurontin. Adverse reactions following the abrupt discontinuation of gabapentin have also been reported. minocin
When Did the FDA Approve Gabapentin for marketing in the United States? If you take Neurontin tablets and break a tablet in half, the unused half of the tablet should be taken at your next scheduled dose. Half tablets not used within 28 days of breaking should be thrown away. Do not suddenly stop taking Neurontin. Patients taking Neurontin to prevent seizures may have an increased risk of seizures if the medicine is suddenly stopped. If you need to stop Neurontin or add a new medicine, your doctor will gradually lower your dose. What should I tell my healthcare provider before taking Neurontin? Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while using Neurontin; it is unknown if Neurontin will harm a fetus. Neurontin passes into breast milk and may harm a nursing baby. Breastfeeding while using Neurontin is not recommended. Neurontin group. In these studies, either Neurontin or placebo was added to the patient's current antiepileptic drug therapy. Store Neurontin capsules between 68 and 77 degrees F 20 and 25 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Neurontin capsules out of the reach of children and away from pets. No interactions between Gabapentin and valproate, carbamazepine or lithium have been reported. For the same population, the responder rate for Neurontin 21% was not significantly different from placebo 18%. What should I avoid while taking Neurontin? Neurontin capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people. The relative risk for suicidal thoughts or behavior was higher in clinical trials for epilepsy than in clinical trials for psychiatric or other conditions, but the absolute risk differences were similar for the epilepsy and psychiatric indications. If you miss a dose of Neurontin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Store Neurontin between 68 and 77 degrees F 20 and 25 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Neurontin out of the reach of children and away from pets. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. buy varenicline tesco pharmacy varenicline
Lasso-de-la-Vega MC, Zapater P, Such J, Perez-Mateo M, Horga JF "Gabapentin-associated hepatotoxicity. Safety and effectiveness of Neurontin in the management of postherpetic neuralgia in pediatric patients have not been established. Neurontin solution is to be used only by the patient for whom it is prescribed. Do not share it with other people. Patients who take Neurontin capsules may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take Neurontin capsules closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur. Aluminum or magnesium containing products may decrease the amount of gabapentin your body absorbs. Like other psychotropic drugs, people should ease off Gabapentin gradually. There are some known withdrawal symptoms. This mostly comes from people who take high doses of the drug and suddenly stop. People should only abruptly discontinue Gabapentin because of a serious side effect. Swallow the capsule whole with plenty of water. Moderate. These medicines may cause some risk when taken together. Is There a Generic Version of Gabapentin Available? PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Neurontin capsules while you are pregnant. Neurontin capsules are found in breast milk. If you are or will be breast-feeding while you use Neurontin capsules, check with your doctor. Discuss any possible risks to your baby. This medication can also cause suicidal thinking. This effect is similar to that of other anticonvulsants. zocor usa store
The increased risk of suicidal thoughts or behavior with AEDs was observed as early as one week after starting drug treatment with AEDs and persisted for the duration of treatment assessed. Because most trials included in the analysis did not extend beyond 24 weeks, the risk of suicidal thoughts or behavior beyond 24 weeks could not be assessed. Table 2 shows absolute and relative risk by indication for all evaluated AEDs. Swallow gabapentin capsules whole with plenty of water. Do not break, crush, or chew before swallowing. Behavioral training and management uses positive reinforcement, self-help, and social skills training to improve behavior and communication. Many types of treatments have been developed, including Applied Behavioral Analysis ABA Treatment and Education of Autistic and Related Communication Handicapped Children TEACCH and sensory integration. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Neurontin solution may cause a serious or life-threatening allergic reaction that may affect your skin or other parts of your body eg, liver, blood cells. A rash may or may not occur along with this reaction. Contact your doctor right away if you develop symptoms such as rash; red, swollen, blistered, or peeling skin; swollen glands or lymph nodes; swelling of the lips or tongue; yellowing of the skin or eyes; unusual bruising or bleeding; severe tiredness or weakness; unusual muscle pain; or symptoms of infection eg, fever, chills, sore throat. Check with your doctor before you drink alcohol or use medicines that may cause drowsiness eg, sleep aids, muscle relaxers while you are using gabapentin capsules; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. There are rare postmarketing reports of individuals experiencing withdrawal symptoms shortly after discontinuing higher than recommended doses of gabapentin used to treat illnesses for which the drug is not approved. Such symptoms included agitation, disorientation and confusion after suddenly discontinuing gabapentin that resolved after restarting gabapentin. Most of these individuals had a history of poly-substance abuse or used gabapentin to relieve symptoms of withdrawal from other substances. The dependence and abuse potential of gabapentin has not been evaluated in human studies. Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes. peda.info zyrtec
Smokers are twice as likely to have a heart attack as nonsmokers, says the AHA. Many studies show that is a major cause of coronary heart disease, which leads to heart attack. If you have trouble giving up smoking on your own, ask your doctor to recommend programs. Michele Bloomquist is a freelance writer based in Portland, Ore. Inform patients that, should they divide the scored 600 mg or 800 mg Neurontin tablet in order to administer a half-tablet, they should take the unused half-tablet as the next dose. Half-tablets not used within 28 days of dividing the scored tablet should be discarded. This decrease in bioavailability was about 10% when gabapentin was administered 2 hours after Maalox. Probenecid Probenecid is a blocker of renal tubular secretion. Gabapentin pharmacokinetic parameters without and with probenecid were comparable. This indicates that gabapentin does not undergo renal tubular secretion by the pathway that is blocked by probenecid. Are There Any Disadvantages to Gabapentin? If you miss a dose of Neurontin capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ragucci MV, Cohen JM "Gabapentin-induced hypersensitivity syndrome. Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonseca V, Hes M, LaMoreaux L, Garafalo E. Gabapentin for the symtomatic treatment of painful neuropathy in patients with diabetes mellitus: A randomized controlled trial. Should a Person Take Any Laboratory Tests Before Taking Gabapentin? Short C, Cooke L "Hypomania induced by gabapentin. What are the possible side effects of Neurontin? If the Neurontin dose is reduced, discontinued, or substituted with an alternative medication, this should be done gradually over a minimum of 1 week a longer period may be needed at the discretion of the prescriber. Taking Neurontin with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider. These therapies are important components of and should all be included in various aspects of the child's treatment program. Speech therapy can help a child with autism improve language and social skills to communicate more effectively. Occupational and physical therapy can help improve any deficiencies in coordination and motor skills. may also help a child with autism to learn to process information from the senses sight, sound, hearing, touch, and smell in more manageable ways. Neurontin in premarketing clinical trials discontinued treatment because of an adverse reaction.
Who should not take Neurontin? Table 3 lists adverse reactions that occurred in at least 1% of Neurontin-treated patients with postherpetic neuralgia participating in placebo-controlled trials and that were numerically more frequent in the Neurontin group than in the placebo group. Ask your health care provider any questions you may have about how to use Neurontin capsules. If you avoid having your children immunized, you put them and others in your community at risk for developing serious diseases, which can cause serious harm or even death. The following adverse reactions have been identified during postmarketing use of Neurontin. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. How is Gabapentin Different From Valproate and Carbamazepine? The starting dose of Neurontin for epilepsy with partial onset seizures in patients 12 years of age and above is 300 mg three times a day. Administer Neurontin three times a day using 300 mg or 400 mg capsules, or 600 mg or 800 mg tablets. The maximum time between doses should not exceed 12 hours. These symptoms may be the first signs of a serious reaction. A healthcare provider should examine you to decide if you should continue taking Neurontin. Each study included a 7- or 8-week double-blind phase 3 or 4 weeks of titration and 4 weeks of fixed dose. Do not change your dose of Neurontin capsules without checking with your doctor. Can This Medication Be Taken with MAO Inhibitors? For all partial seizures in the intent-to-treat population, the response ratio was statistically significantly better for the Neurontin group -0. Among the adverse reactions occurring at an incidence of at least 10% in Neurontin-treated patients, somnolence and ataxia appeared to exhibit a positive dose-response relationship. cost of clomiphene with insurance
Adapted from: Emanuel, LL, von Gunten, CF, Ferris, FF eds. Because of the short half-life of the medication, people will need to take divided doses throughout the day. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Neurontin may interfere with certain lab tests, including a certain urine protein test. Be sure your doctor and lab personnel know you are taking Neurontin. Neurontin can pass into breast milk. You and your healthcare provider should decide how you will feed your baby while you take Neurontin. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Neurontin to assess whether Neurontin impairs their ability to perform such tasks. Partial seizures when taken together with other medicines in adults and children 3 years of age and older with seizures. If Taken In Overdose, is Gabapentin Toxic? It is not known if Neurontin can harm your unborn baby. Tell your healthcare provider right away if you become pregnant while taking Neurontin. You and your healthcare provider will decide if you should take Neurontin while you are pregnant. buy clopidogrel online cheap uk
The FDA placed Gabapentin in pregnancy category C. According to studies done on animals, there was harm done to fetuses. However, there have been no studies done on humans. Despite all this, experts believe that the benefits gained from taking Gabapentin may outweigh its risks. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Warning: Right now, Gabapentin is approved in the United States to treat seizures. There are not a lot of comprehensive studies that look at Gabapentin as a way to treat anxiety, mood disorders or tardive dyskinesia. Even though there are studies in the works, what experts know about Gabapentin for the purpose of controlling anxiety and mood disorders and tardive dyskinesia mostly comes from faulty case reports. There have been double-blind studies done, but they have not proved that Gabapentin works as a mood stabilizer. The risk of suicidal thoughts or behavior was generally consistent among drugs in the data analyzed. The finding of increased risk with AEDs of varying mechanisms of action and across a range of indications suggests that the risk applies to all AEDs used for any indication. What is the most important information I should know about Neurontin? Gabapentin has a half-life of about six hours, so it must be administered 3 to 4 times a day. Know your genetic risk: If close family members grandparents, parents, siblings have had heart disease, you may be at additional risk. Make sure to let your doctor know your family history. But remember, not having family members with heart disease doesn't make you immune; your lifestyle still plays a role. Plus background antiepileptic drug therapy Amblyopia was often described as blurred vision. Signs of acute toxicity in animals included ataxia, labored breathing, ptosis, sedation, hypoactivity, or excitation. Response ratio was also better in the Neurontin group -0. This section provides information on the proper use of a number of products that contain gabapentin. It may not be specific to Neurontin. Please read with care. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Crawford P, Ghadiali E, Lane R, Blumhardt L, Chadwick D "Gabapentin as an antiepileptic drug in man. BMI of between 21 and 25 is ideal, according to the AHA. BMI equals a person's weight in kilograms divided by height in meters squared. Early diagnosis and treatment helps young children with develop to their full potential. The primary goal of treatment is to improve the overall ability of the child to function. cetirizine
Do not take an antacid containing aluminum or magnesium within 2 hours before you take Neurontin solution. Can Children and Adolescents Safely Take Gabapentin? Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. It is freely soluble in water and both basic and acidic aqueous solutions. Health care providers should exercise their own independent clinical judgment. Some Fast Fact information cites the use of a product in dosage, for an indication, or in a manner other than that recommended in the product labeling. Accordingly, the official prescribing information should be consulted before any such product is used. Some medical conditions may interact with Neurontin capsules. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Evidence of effectiveness was obtained in three trials conducted in 705 patients age 12 years and above and one trial conducted in 247 pediatric patients 3 to 12 years of age. The patients enrolled had a history of at least 4 partial seizures per month in spite of receiving one or more antiepileptic drugs at therapeutic levels and were observed on their established antiepileptic drug regimen during a 12-week baseline period 6 weeks in the study of pediatric patients. In patients continuing to have at least 2 or 4 in some studies seizures per month, Neurontin or placebo was then added on to the existing therapy during a 12-week treatment period. Advise patients that Neurontin may cause dizziness, somnolence, and other symptoms and signs of CNS depression. Other drugs with sedative properties may increase these symptoms. The use of Neurontin in patients less than 12 years of age with compromised renal function has not been studied. Neurontin capsules may cause a serious or life-threatening allergic reaction that may affect your skin or other parts of your body eg, liver, blood cells. A rash may or may not occur along with this reaction. Contact your doctor right away if you develop symptoms such as rash; red, swollen, blistered, or peeling skin; swollen glands or lymph nodes; swelling of the lip or tongue; yellowing of the skin or eyes; unusual bruising or bleeding; severe tiredness or weakness; unusual muscle pain; or symptoms of infection eg, fever, chills, sore throat. avlocardyl
Sedation and confusion, as well as dizziness and ataxia, are the most common side effects, especially with rapid dose titration. Tolerance to these effects appears to develop within a few days if the dose is held at the highest tolerated dose until symptoms improve or stabilize. This may not be a complete list of all interactions that may occur. Ask your health care provider if Neurontin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. The US, Gabapentin Study Group No. 5 "Gabapentin as add-on therapy in refractory partial epilepsy: a double-blind, placebo-controlled, parallel-group study. Changes in behavior and thinking - Using Neurontin in children 3 to 12 years of age can cause emotional changes, aggressive behavior, problems with concentration, restlessness, changes in school performance, and hyperactivity. 3. Neurontin may cause serious or life-threatening allergic reactions that may affect your skin or other parts of your body such as your liver or blood cells. This may cause you to be hospitalized or to stop Neurontin. You may or may not have a rash with an allergic reaction caused by Neurontin. PO qod. For patients on hemodialysis: max 200-300mg dose only after each dialysis session. This information should not be used to decide whether or not to take Neurontin capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Neurontin capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Neurontin capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Neurontin capsules. The following adverse reactions have been identified during postmarketing use of NEURONTIN. Knowing the signs of an attack can help you recognize the emergency and get lifesaving treatment in time. Kishore A and King L. Gapapentin for neuropathic pain. September, 2001. End-of-Life Physician Education Resource Center www. Take Neurontin by mouth with or without food.
Ask your health care provider any questions you may have about how to use Neurontin solution. The drug interaction data described in this section were obtained from studies involving healthy adults and adult patients with epilepsy. The clinical significance of this finding is unknown. Clinical experience during gabapentin's premarketing development provides no direct means to assess its potential for inducing tumors in humans. The effectiveness of Neurontin as adjunctive therapy added to other antiepileptic drugs was established in multicenter placebo-controlled, double-blind, parallel-group clinical trials in adult and pediatric patients 3 years and older with refractory partial seizures. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of gabapentin for treating partial seizures in children. However, safety and efficacy have not been established in children younger than 3 years of age. Use with caution. May make these conditions worse. Studies designed to investigate the mechanism of gabapentin-induced pancreatic carcinogenesis in rats indicate that gabapentin stimulates DNA synthesis in rat pancreatic acinar cells in vitro and, thus, may be acting as a tumor promoter by enhancing mitogenic activity. It is not known whether gabapentin has the ability to increase cell proliferation in other cell types or in other species, including humans. Do not take an antacid containing aluminum or magnesium within 2 hours before you take Neurontin capsules. Some MEDICINES MAY INTERACT with Neurontin. Neurontin comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Neurontin refilled. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. purchase cheap pantoprazole otc
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Patients had up to 48 hours of baseline and up to 72 hours of double-blind video EEG monitoring to record and count the occurrence of seizures. There were no statistically significant differences between treatments in either the response ratio or responder rate. Gabapentin caused a marked decrease in neuronal synapse formation in brains of intact mice and abnormal neuronal synapse formation in a mouse model of synaptic repair. Gabapentin has been shown in vitro to interfere with activity of the α2δ subunit of voltage-activated calcium channels, a receptor involved in neuronal synaptogenesis. The clinical significance of these findings is unknown.
Take gabapentin capsules by mouth with or without food. Renal clearance CLr and CLr adjusted for body surface area also declined with age; however, the decline in the renal clearance of gabapentin with age can largely be explained by the decline in renal function. This medicine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions. Neurontin can cause serious side effects including: 1. Suicidal Thoughts. Like other antiepileptic drugs, Neurontin may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.
Gabapentin works in the brain to prevent seizures and relieve pain for certain conditions in the nervous system. It is not used for routine pain caused by minor injuries or arthritis. Gabapentin is an anticonvulsant. Neurontin tablets can be taken with or without food. Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
Always consult a healthcare professional for medical advice. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Neurontin for a condition for which it was not prescribed. Do not give Neurontin to other people, even if they have the same symptoms that you have. It may harm them. Antiepileptic drugs should not be abruptly discontinued because of the possibility of increasing seizure frequency.